Fluidization of fine lactose for dry powder inhalation: A comparison of assisting methods
نویسندگان
چکیده
Fluidization of cohesive pharmaceutical powders is difficult to achieve and typically requires the introduction external forces. This study investigates fluidization fine inhalation grade lactose (size range from 0.1-20 μm) that are specifically developed for dry powder (DPI) applications. The behaviour was evaluated under six conditions: without aids, with only vertical vibration (VFA), a downward-pointing micro-jet (MFA), both pre-mixing coarse particles (VCFA), (VMFA), combined assistance vibration, micro-jet, addition (VMCFA). enhancement due use different methods reflected by increase bed expansion decrease in minimum velocity agglomerate formation. However, applying results considerable losses high fraction stuck wall. Combining any two assisting leads better than using single approach. In particular, combination shows best performance improving fluidization. Further does not play significant influence on promoting Finally, analysis forces acting agglomerates separation introducing assistance, which size.
منابع مشابه
Particulate Interactions in Dry Powder Formulations for Inhalation Particulate Interactions in Dry Powder Formulations for Inhalation
متن کامل
Evaluation of flow properties of dry powder inhalation of salbutamol sulfate with lactose carrier.
The effects of the flow and packing properties of a drug/carrier powder mixture on emission of drug adhering to the carrier from capsules and inhalation devices were investigated. Model powder mixtures were designed consisting of lactose carriers with different particle shapes were prepared by surface treatment and micronized salbutamol sulfate. These powder mixtures were aerosolized by a Spinh...
متن کاملPreparation of dry powder inhalation by surface treatment of lactose carrier particles.
An attempt was made to produce carrier particles for dry powder inhalations by the surface treatment of lactose particles with aqueous ethanol solution. Drug/carrier powder mixtures were prepared consisting of lactose carriers with different particle surface properties and micronized salbutamol sulfate. These powder mixtures were aerosolized by Spinhaler, and in vitro deposition properties of s...
متن کاملa comparison of linguistic and pragmatic knowledge: a case of iranian learners of english
در این تحقیق دانش زبانشناسی و کاربردشناسی زبان آموزان ایرانی در سطح بالای متوسط مقایسه شد. 50 دانش آموز با سابقه آموزشی مشابه از شش آموزشگاه زبان مختلف در دو آزمون دانش زبانشناسی و آزمون دانش گفتار شناسی زبان انگلیسی شرکت کردند که سوالات هر دو تست توسط محقق تهیه شده بود. همچنین در این تحقیق کارایی کتابهای آموزشی زبان در فراهم آوردن درون داد کافی برای زبان آموزان ایرانی به عنوان هدف جانبی تحقیق ...
15 صفحه اولExploring the potential of mannitol as an alternative to lactose in dry powder inhalation
is well established in formulations for dry powder inhalation, as it overcomes problems of micronized drug particles often being cohesive and poorly flowable and hence, creating difficulties in powder handling and dosing. In carrier-based blends, micronized drug is adhered on the surface of the carrier and thus, is moved and dosed as if it were a larger particle. For nasal administration, parti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Journal of Chemical Engineering
سال: 2021
ISSN: ['0008-4034', '1939-019X']
DOI: https://doi.org/10.1002/cjce.24002